［1］NICULESCU M D.Nutritional epigenetics［J］.Ins Lab Anim Res，2012，53(3-4)：270-278.
［2］FEIL R.Environmental and nutritional effects on the epigenetic regulation of genes［J］. Mutat Res，2006，600(1-2)： 46-57.
［3］ANDERSON O S，SANT K E，DOLINOY D C.Nutrition and epigenetics：an interplay of dietary methyl donors，one-carbon metabolism and DNA methylation［J］.J Nutr Biochem，2012，23(8)：853-859.
［4］GLUCKMAN P D，HANSON M A，SPENCER H G，et al.Environmental influences during development and their later consequences for health and disease：implications for the interpretation of empirical studies［J］.Proc Royal Soc B：Biol Sci，2005， 272(1564)：671-677.
［5］WU G，BAZER F M，WALLACE J M，et al.Board-invited review：Intrauterine growth retardation：Implications for the animal sciences［J］.J Anim Sci，2006，84(9)：2316-2337.
［6］SYMONDS M E，STEPHENSON T，GARDNER D S，et al.Long-term effects of nutritional programming of the embryo and fetus：mechanisms and critical windows［J］. Reprod Fert Dev，2007，19(1)：53.
［7］JIMÉNEZ-CHILLARÓN，JOSEP C D，RUBÉN M，et al.The role of nutrition on epigenetic modifications and their implications on health［J］.Biochimie，2012，94(11)：2242-2263.
［8］GUILLOTEAU P，ZABIELSKI R，HAMMON H M，et al.Padverse effects of nutritional programming during prenatal and early postnatal life，some aspects of regulation and potential prevention and treatments［J］. J Physiol Pharmacol，2009，603：17-35.
［9］RUEMMELE F M，GARNIER-LENGLINÉ H.Why are genetics important for nutrition? Lessons from epigenetic research［J］.Ann Nutr Metab，2012， 60(S3)： 38-43.
［10］REIK W，DEAN W，WALTER J.Epigenetic reprogramming in mammalian development［J］.Science，2001，293(5532)：1089-1093.
［11］WADDINGTON C H.The strategy of genes［M］.London：Allen & Unwin，1958.
［12］HALL B K.Evolutionary developmental biology［M］.London：Chapman & Hall，1992.
［13］WOLFFE A P，MATZKE M A.Epigenetics：Regulation through repression［J］.Science，1999，286(5439)：481-486.
［14］GRAVINA S，VIJG J.Epigenetic factors in aging and longevity［J］.Pflugers Archiv-Eur J Physiol，2010，459(2)：247-258.
［15］SKINNER M K.Role of epigenetics in developmental biology and transgenerational inheritance［J］.Birth Defects Res Part C-Embryo Today-Rev，2011，93(1)：51-55.
［16］MOHR F，DOHNER K，BUSKE C，et al.TET Genes：new players in DNA demethylation and important determinants for stemness［J］.Exp Hematol，2011，39(3)：272-281.
［17］NICULESCU M D，LUPU D S.Nutritional influence on epigenetics and effects on longevity［J］.Current Opin Clin Nutr Metab Care，2011，14(1)：35-40.
［18］MATZKE M A，BIRCHLER J A，RNAi-mediated pathways in the nucleus［J］.Nat Rev Genet，2005，6(1)：24-35.
［19］PETRONIS A.Epigenetics and twins：three variations on the theme［J］.Trends Genet，2006，22(7)：347-350.
［20］JAENISCH R.DNA methylation and imprinting：Why bother?［J］.Trends Genet，1997，13(8)：323-329.
［21］JONES P A，GONZALGO M L.Altered DNA methylation and genome instability：A new pathway to cancer?［J］.Proc Natl Acad Sci U S A，1997， 94(6)：2103-2105.
［22］ROBERTSON K D，WOLFFE A P.DNA methylation in health and disease［J］.Nat Rev Genet，2000， 1(1)：11-19.
［23］PTAK C，PETRONIS A.Epigenetics and complex disease：From etiology to new therapeutics［J］. Ann Rev Pharmacol Toxicol，2008，48：257-276.
［24］JONES P A，LIANG G N.Opinion rethinking how DNA methylation patterns are maintained［J］.Nat Rev Genet，2009，10(11)：805-811.
［25］USHIJIMA T，ASADA K.Aberrant DNA methylation in contrast with mutations［J］.Cancer Sci，2010，101(2)：300-305.
［26］OLLIKAINEN M，SMITH K R，JOO E J H，et al.DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome［J］.Hum Mol Genet，2010，19(21)：4176-4188.
［27］MCKAY J A，MATHERS J C.Diet induced epigenetic changes and their implications for health［J］. Acta Physiologica，2011，202(2)：103-118.
［28］SUZUKI M M，BIRD A.DNA methylation landscapes：provocative insights from epigenomics［J］.Nat Rev Genet，2008，9(6)：465-476.
［29］JELTSCH A.Beyond Watson and Crick：DNA methylation and molecular enzymology of DNA methyltransferases［J］.Chembiochem，2002，3(4)：275-293.
［30］NICULESCU M D，ZEISEL S H.Diet，methyl donors and DNA methylation：Interactions between dietary folate，methionine and choline［J］. J Nutr，2002，132S(8)：2333S-2335S.
［31］BONIFER C，COCKERILL P N.Chromatin mechanisms regulating gene expression in health and disease［J］.Epigenet Contribut Autoimmu Dis，2011，711：12-25.
［32］KAMINEN-AHOLA N J，AHOLA A I，WHITELAW W.Nutrition in Epigenetics-Epigenetic inheritance：Both mitotic and meiotic［M］.Lowa：Blackwell publish， 2011.
［33］AUFSATZ W，METTE M F，MATZKE M，et al.The role of MET1 in RNA-directed de novo and maintenance methylation of CG dinucleotides［J］.Plant Mol Biol，2004，54(6)：793-804.
［34］MATHERS J C.Session 2：Personalised nutrition Epigenomics：a basis for understanding individual differences?［J］. Proc Nutr Soc，2008，67(04)：390.
［35］FORET S，KUCHARSKI R，PELLEGRINI M，et al.DNA methylation dynamics，metabolic fluxes，gene splicing，and alternative phenotypes in honey bees［J］.Proc Natl Acad Sci U S A，2012，109(13)：4968-4973.
［36］VAN STRATEN E M E，BLOKS V W，HUIJKMAN N C A，et al.The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction［J］.Am J Physiol Regul Inteqr Comp Physiol，2010，298(2)：R275-R282.
［37］REES W D，HAY S M，BROWN D S，et al.Maternal protein deficiency causes hypermethylation of DNA in the livers of rat fetuses［J］.J Nutr，2000，130(7)：1821-1826.
［38］BOGDARINA I，HAASE A，LANGLEY-EVANS S，et al.Glucocorticoid effects on the programming of AT1b angiotensin receptor gene methylation and expression in the rat［J］. PLoS ONE，2010，5：e92372.
［39］CARONE B R，FAUQUIER L，HABIB N，et al.Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals［J］.Cell，2010，143(7)： 1084-1096.
［40］LILLYCROP K A，SLATER-JEFFERIES J L，HANSON M A，et al.Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications［J］.Br J Nutr，2007，97(06)：1064.
［41］WATERLAND R A.Assessing the effects of high methionine intake on DNA methylation［J］.J Nutr，2006，136S(6)：1706S-1710S.
［42］AMARAL C L D，BUENO R D B，BURIM R V，et al.The effects of dietary supplementation of methionine on genomic stability and p53 gene promoter methylation in rats［J］. Mutat Res，2011，22(1)：78-83.
［43］DEVLIN A M，ARNING E，BOTTIGLIERI T，et al.Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice［J］.Blood，2004，103(7)：2624-2629.
［44］DUDLEY K J，SLOBODA D M，CONNOR K L，et al.Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation［J］.PLoS ONE，2011，6(7)：e21662.
［45］VUCETIC Z，KIMMEL J，TOTOKI K，et al.Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes［J］. Endocrinology，2010，151(10)：4756-4764.
［46］VUCETIC Z，KIMMEL J，REYES T M.Chronic high-fat diet drives postnatal epigenetic regulation of μ-opioid receptor in the brain［J］. Neuropsychopharmacology，2011，36(6)：1199-1206.
［47］VUCETIC Z，KIMMEL J，REYES T M.Epigenetic dysregulation of the dopamine system in diet-induced obesity［J］.J Neurochem，2012,120：891-898.
［48］MCKAY J A，WALTHAM K J，WILLIAMS E A，et al.Folate depletion during pregnancy and lactation reduces genomic DNA methylation in murine adult offspring［J］.Genes Nutr，2011，6(2)：189-196.
［49］CHRISTENSEN K E，WU Q，WANG X，et al.Steatosis in mice is associated with gender，folate intake，and expression of genes of one-carbon metabolism［J］.J Nutr，2010，140(10)：1736-1741.
［50］LY A，LEE H，CHEN J，et al.Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring［J］.Cancer Res，2011，71(3)：988-997.
［51］BURDGE G C，LILLYCROP K A，PHILLIPS E S，et al.Folic acid supplementation during the juvenile-pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition［J］.J Nutr，2009，139(6)：1054-1060.
［52］KULKARNI A，DANGAT K，KALE A，et al.Effects of Altered maternal folic acid，vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats［J］.PLoS ONE，2011，6(3)：e17706.
［53］VINEIS P，CHUANG S C，VAISSIÈRE T，et al.DNA methylation changes associated with cancer risk factors and blood levels of vitamin metabolites in a prospective study［J］.Epigenetics，2011，6(2)：195-201.
［54］KOVACHEVA V P，MELLOTT T J，DAVISON J M，et al.Gestational choline deficiency causes global and IGF2 gene DNA hypermethylation by up-regulation of Dnmt1 expression［J］. J Biol Chem，2007，282(43)：31777-31788.
［55］DU Y，PENG J S，SUN A，et al.Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model［J］. BMC Cancer，2009，9(1)：261.
［56］DAVIS C D，UTHUS E O，FINLEY J W.Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 Cells and in vivo in rat liver and colon［J］.J Nutr，2000，130(12)：2903-2909.
［57］TANDON S K，MAGOS L，WEBB M.The stimulation and inhibition of the exhalation of volatile selenium［J］.Biochem Pharmacol，1986，35：2763-2766.